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Last Edited May 28, 2019

The New Era of Ana

Here's a Save update!

With the recent buffs to her kit, Ana has been a high-priority pick for me in my ranked-play climb. Although she may not be as difficult initially to play as she once was, I still believe her skill-cap is very high and can be utilized by the experienced support player in a way unlike any other support in the game. The heal denial mixed with a surprise amount of burst-healing makes her one of the best supports in the game right now.

Below is the build I bring to the table most games.

Let me know if you have any questions in the comments!
Contact Healing
Biotic Grenade heals for 30% more per allied and enemy Hero hit.
Right out of the gates, we're looking at Grenade healing for 166 Health on a 16-second cooldown, which is nothing really to write home about. However, if you are coordinating with your teammates and you group up for a heal, this selection provides for a 150% Heal buff when hitting yourself and your four homies, which is a 415 HP heal for each teammate (2,075 in total).

To put that into perspective, Uther's Q heals for a total of 543 between his target (362) and himself (181) on a 12-second cooldown. Rehgar's Q heals for a max of 780 on an 8-second cooldown if you properly bridge the heal to three teammates. But wait, there’s more. The text lawyers us a bit with “per allied AND enemy Hero hit” — this gets wild if we also hit two or three opponents as well. Not only are we cutting their heals completely, we are buffing the heals on our own teammates even further.

Pretty Spicy.
Biotic Enhancements
Increase the bonus healing duration of Biotic Grenade by 50% and reduce its cooldown by 2 seconds.
Bio here is clutch. Not only does it provide for a larger window to drop some crit darts, but it reduces the cool down of our Grenade from 16 to 12 seconds. This increases our throughout considerably in team fits, allowing us to Grenade 2-3 times instead of just once or twice.?
Increase the area of Biotic Grenade by 25% and the duration of the healing reduction by .75 seconds
This just makes our life easier on all fronts. We zap their heals for longer (from two seconds to now three seconds), but it Grenade’s AOE splash is 100% larger, which only helps the synergy from Level 1.
Eye of Horus
Assume a sniping position, gaining the ability to fire up to 6 specialized rounds with unlimited range. Rounds pierce allied and enemy Heroes but collide with enemy Structures in their path. Allies are healed for 225 and enemies are damaged for 135. Deals 50% less damage to Structures. Ana is unable to move while Eye of Horus is active.
I like Horus, even with the nerf. If you have a mage on your team that is hot shit, Nano works, too.
Purifying Darts
Healing Dart removes Roots and Slows from the target, and heals for 20% more when doing so.
13 is a situational talent tier. If you’re going up against a team with two or three Heroes with Root and Slow abilities, which tends to be the case these days, grab Purifying Dart to keep your team safe from too much lock down. Same story for Smelling Salts when it comes to going up against a Diablo, Kael’thas, or Uther. ??All of this being said, one could make an argument for being pro-active and simply giving your homies that nice 25% speed boost with Speed Serum — the best defense is a good offense sometimes.
Concentrated Doses
Increase Healing Dart's healing by 10% for each Dose active on enemy Heroes.
Although Sharpshooter is tempting with a near-constant 50% buff to your Q, I’ve been leaning on Concentrated Doses simply because I tend to be able to keep six Shrikes up on enemy Heroes pretty consistently. On the other end of the spectrum, Active Reload can be skilled into situations as a burst heal, which is definitely worth consideration once you get comfortable with playing Ana under pressure.
Dynamic Optics
Basic Attacks increase Attack Speed by 10% for 3 seconds, up to 100%. While Aim Down Sights is active, increase your Basic Attack Range by 4.
When it comes to Storm talents, the Heroic upgrades are fine picks and really any of these selections will bring you an advantage. I, personally, prefer Dynamic Optics when taking Concentrated Doses due to the insane synergy between the two — it’s also fun as hell to pew-pew like crazy.
Balance Patch - 01/03/19
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Love this build, although I do like running Vampiric Darts if I'm going to go Concentrated Doses. I know the Grenade build is the strongest healing build for Ana but when would it be good to go this build and in other cases when would Vampiric Darts/Dose build be good?